Name: CJC-1295 DAC 5mg
Brand: Nuvopeptide
SKU: cjc-1295-dac-5mg
Price: 167 USD
Availability: OutOfStock

Question 1

What is the "Drug Affinity Complex" and how does it work?

Accepted Answer

The DAC modification involves a maleimidoproprionic acid (MPA) group attached to the C-terminus of CJC-1295. In plasma, this reactive group forms a stable thioether bond with cysteine-34 of albumin — the most abundant plasma protein. The resulting peptide-albumin complex is too large for renal filtration and is protected from proteases, extending half-life from hours (without DAC) to approximately 7-8 days.

Question 2

Why would a researcher choose CJC-1295 DAC over the non-DAC version?

Accepted Answer

The choice depends on the research question. CJC-1295 without DAC is preferred when studying physiological pulsatile GH secretion patterns or when discrete dosing windows are important. CJC-1295 DAC is preferred for studying sustained GHRH receptor engagement, maintaining elevated IGF-1 levels over longer periods, or for convenience in long-duration protocols requiring less frequent administration.

Question 3

Does CJC-1295 DAC cause receptor desensitization?

Accepted Answer

This is an active research question. Sustained GHRH receptor stimulation, unlike the brief activation from native GHRH, could in theory produce receptor internalization or post-receptor desensitization. Research with CJC-1295 DAC has explored this question in pituitary cell culture and animal models, with results suggesting that GH responsiveness may be maintained despite prolonged receptor engagement under certain conditions.

Question 4

Is CJC-1295 DAC appropriate for combination with ipamorelin?

Accepted Answer

Yes. CJC-1295 DAC is commonly combined with ipamorelin in research protocols. The DAC formulation provides continuous GHRH receptor background stimulation while ipamorelin provides pulsatile GHS-R1a activation. The synergistic GH release from complementary signaling pathways remains active regardless of the DAC modification.

CJC-1295 DAC 5mg

For Research Use Only

Description

Research Summary

Storage & Handling

Storage Temperature

Reconstitution

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